Longitudinal analysis of disability outcomes among young people with MS

BackgroundThe age of onset MS appears to influence the course disease progression and people with younger might have a different disability trajectory.ObjectivesTo identify longitudinal patterns progression, as measured by changes in Multiple Sclerosis Functional Composite (MSFC), young drug trials estimate extent which differ two groups (≤25 years 26 – 35 years).MethodsData from Outcomes Assessment Consortium (MSOAC) was used. Longitudinal on MSFC were identified using group-based trajectory models (GBTM). For difference between expected observed proportions pediatric-onset chi-square statistic Linear mixed used average change performance over time, sex.ResultsGBTM results showed little variability time. Mixed modeling that group performed better for gait speed, dexterity, cognition. Men poorer dexterity Distribution differed cognition, EDSS.ConclusionsThe combined use linear provided rich information about function